MSM Product Buyer’s Guide (updated May 2024)

Information About MSM

While methylsulfonylmethane, better known as MSM, can be found in different types of food, it is in small amounts and the cooking process destroys its integrity negatively affecting its efficacy. Additionally, since quantities of MSM are in small derivatives, it’s not possible to extract or isolate it in order to be encapsulated in an MSM supplement. Therefore, the only way to manufacture MSM is via a chemical reaction. This means that the original source of MSM won’t make a difference to the end product. What WILL make a difference to the quality of MSM supplements, is the purification process and manufacturer testing.

There are 2 ways to separate the MSM after a chemical reaction, either by crystallization or distillation. Crystallization separates the MSM by cooling the solution which can form occlusions (small pockets or imperfections) that can entrap impurities. Distillation includes boiling the solution which is vaporized and distilled for a 99.9% pure MSM product. Distillation requires more energy and is a more expensive separation technique. Distillation is clinically proven to be the superior separation method for MSM purification. 

The highest standard of purity is essential to achieve optimal health results without the potentially dangerous health issues from impurities. OptiMSM® is currently the only MSM that uses distillation for purification.

Because of this, there are many MSM supplements out there that don’t actually work. That is until now!

Given the right formula, from a quality manufacturer that has based their product upon scientific research and clinical data, there are MSM supplements out there that will do exactly what they say they will with many people experiencing incredible results. Our research has shown that given the correct dosage and potency of 100% pure MSM – you can achieve the results that you want.

There are several key elements which make a highly effective, top-quality MSM supplement. These include 100% pure OptiMSM® that has been purified in a 4-stage distillation process. It must provide at least a 2000mg daily dose of MSM for optimal health benefits. It must include a thermogenic ingredient to increase bioavailability so it will be absorbed easily for faster and more effective results. Clinical studies further support the benefits of such key ingredients with many participants experiencing positive results.

Key points to consider when choosing an MSM supplement

Of course, you will be dubious, so were we. Many manufacturers of health care supplements make grand promises of renewed health, only to find out a month later that there is no real change and you are left with an empty bottle, empty purse, and empty promises. Don’t dismay – there are some that really do work – you just need to find a genuine product.

As soon as a new product hits the market, dozens of manufacturers appear, almost overnight, to try to jump on board. As a result, consumers need to be on the lookout for many products that are watered down and quite frankly ineffective, promising results that are totally unrealistic and undeliverable.

When choosing an MSM supplement, you should look for a company with a strong reputation that sells a wide range of nutritional natural dietary health supplements. An effective supplement will be formulated using high-quality MSM that has been proven effective in clinical trials and is GRAS-designated and GMP certified as well as FDA registered for the purest and most absorbable product for powerful results.

If you come across a company selling MSM supplements using strong marketing terms or slogans, or are endorsed by famous celebrities, you should stay clear. If the company and product formula don’t speak for themselves, then nothing else should.  

Should you decide that an MSM supplement is for you, and you would like to try a top-quality product, check out our reviews for a number of MSM supplements that are currently available on the market. We examined numerous products for their ingredients, consumer feedback, business reputation and much more to help you discover which supplements are the real deal! You no longer need to search Google for your answers, no more guesswork, we have done all the hard work for you.

What makes an MSM supplement effective?

The secret is simply in the formula! Using the correct dosage and potency of clinically-proven key ingredients will help achieve results like nothing else. Key specifications such as third-party certifications for purity and safety, 100% OptiMSM®, a high dosage of 2000mg of pure MSM, and a thermogenic ingredient to enhance MSM’s bioavailability have been shown to be essential for providing increased antioxidant benefits and improved health.

Our recommended choice stands above and beyond the competition, we think you will agree. The company’s excellent reputation, high-quality product, external independent monitoring, and testing, coupled with an incredible money-back guarantee policy, makes this a formula that you are going to want to take a closer look at.


MSM Report

Rating: Excellent


Money Back Guarantee
Consumer Feedback
Company Reputation

Editor’s Choice

Approved Science MSM

If you are looking to improve your overall health by strengthening connective tissue for a difference you can feel throughout your body, then Approved Science MSM is something that deserves your undivided attention. Of all the MSM supplements currently available on the market, this is the one that deserves a closer look and very likely, the one that will change your life!

It contains the highest quality, clinically-proven, OptiMSM® which is the only MSM to have the GRAS (generally recognized as safe) designation for its purity. The unique 4-stage distillation process ensures a product that really works because it is free of impurities that make other products less effective. It was the only product we found that contains a whopping 2000mg daily serving of MSM for reducing inflammation, improving joint health, clearing skin irritations, boosting the immune system and easing allergy symptoms. In addition, it contains BioPerine®, a thermogenic ingredient that enhances the body’s ability to absorb and utilize MSM for greater health benefits. It does not contain any additives or preservatives and is totally 100% safe to use with no long-term side effects.

Quality: Approved Science MSM contains high-grade, natural, clinically-verified ingredients that are GMP certified, FDA registered and contains OptiMSM® which is third-party tested for 100% purity. 

Reputation: Their reputation is top quality. This manufacturer has several third-party monitoring services, including buySAFE, Norton, and Trustee, as well as an A+ rating from the quality monitoring company QualityTrusted.

Money Back Guarantee: Every item sold is supported by a 60-day 100% money-back guarantee. Such guarantees from manufacturers show strong confidence in their products’ ability to deliver results. Great news for consumers.

What’s more, they are well known in the industry and an established company that provides great customer support service, secure and easy checkout as well as prompt, efficient delivery.

Their commitment to the health industry and consumers is excellent, providing further qualification of efficacy by producing their products in an FDA registered laboratory.

If you are looking for a product that ticks all the boxes for an effective MSM supplement, from an established reputable company with an excellent money-back guarantee, this is the supplement for you.

It would be good to note that, due to high demand, Approved Science MSM is often sold out. To avoid having to back order, don’t hesitate to make that purchase when you see it in stock.

See The Full Review


Rating: Good



Douglas Laboratories MSM Capsules

Promoted as a health product to help support healthy connective tissues, lungs and joints, Douglas Laboratories MSM Capsules is our next product up for review. This manufacturer has a good reputation and this product contains OptiMSM® for the purest MSM on the market. But is this enough to compensate for this product’s low daily serving? 

When reviewing this product, we were pleased to see a price tag that suggests quality – not cheap, but definitely affordable. We appreciated that this product is formulated with OptiMSM® as it has a multi-stage distillation process and each batch is third-party tested for purity. However, it is unclear to us if this double-strength formula will actually be effective. With 750mg of MSM, Douglas Laboratories has manufactured a product that contains less than half of the dose of our Editor’s #1 Choice. 

Additionally, there is no thermogenic ingredient added to the formula which would serve to boost the bioavailability of the MSM ensuring that sulfur is delivered to the entire body more effectively. Still, consumers might be interested in trying this product for themselves as it is certainly is a safe option as far as we can see. However, there are 2 caveats. One is that there is gelatin in this product and therefore not suitable for vegans, vegetarians or people who follow kosher or halal rules. The second caveat is that because Douglas Laboratories sell directly to healthcare providers, it is not possible to purchase from the manufacturer themselves. While it is possible to buy from Amazon, it is unclear if the return policy would still apply. Even if it does, consumers should be aware that it is only applicable for 30 days and requires authorization. Continue reading our review to see if this product is worth your time and money.

Click here to read the full review


Rating: OK


Designs for Health MSM

Designs for Health MSM claims to be a company that is trusted by over 50,000 practitioners. This is quite a bold claim! In our review of this MSM product, we were a bit puzzled and interested to know what all those practitioners would think of this formulation. We can’t speak for all of their products, but this one seemed to be missing some crucial aspects for a quality MSM supplement.  

The most troubling aspect of this product is the absence of OptiMSM®. As this is the top MSM on the market and known for its high quality and third-party testing, it was disappointing not to see it here. We would have hoped to see some transparency from the manufacturer as to their process of purifying their MSM. While distillation is the preferred method of isolating MSM, it is also a lot more costly. When companies do not disclose their purification process, we assume they use the more inexpensive route of crystallization. Unfortunately, part of this method includes cooling down the MSM which can lead to occlusions that trap contaminants and lead to an impure product. 

So what exactly is in these pills? They contain 1 gram of MSM but may also contain impurities such as heavy metals. At best, these can get in the way of an effective product. At worst, they can cause serious harm if you ingest them. We examined customer reviews but there were too few for us to get a good idea of what consumers can expect. We were pleased to see that there is a return policy but it is only for 30 days and only applicable for unopened bottles so it is not possible to try this product out to find out if it works. Continue reading our full review to see the full picture of this product.

Click here to read the full review


What You’ll Discover:

Which MSM supplement is the BEST BUY and comes with a great GUARANTEE!
Which formula and ingredients are the most EFFECTIVE and work the fastest?
How NOT to get ripped off! BE AWARE of poor quality and cheap products.

Top 6 Items to Consider:

  1. Ingredients
  2. Cost Per Serving
  3. Product’s Testing Results
  4. Company’s Reputation
  5. Consumer Reviews
  6. Return Policy & Satisfaction Guarantee

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